Goyal Nishant, Nizamie S Haque, Desarkar Pushpal
Adult Psychiatry Unit, Central Institute of Psychiatry, Kanke (PO), Ranchi-834006, Jharkhand, India.
J Neuropsychiatry Clin Neurosci. 2007 Fall;19(4):464-7. doi: 10.1176/jnp.2007.19.4.464.
The potential effect of repetitive transcranial magnetic stimulation (rTMS) on core positive and negative symptoms in schizophrenia has not yet been clearly established. The aim of this study was to examine the efficacy of adjuvant 10 Hz, suprathreshold left prefrontal rTMS in negative symptoms of schizophrenia in a double-blind sham-controlled design. Additionally, our study also investigated the suitability of applying the same stimulus condition on positive symptoms. Ten right-handed schizophrenia patients received sham or active 10 Hz suprathreshold rTMS to the left dorsolateral prefrontal cortex with psychopathology, depression and global improvement ratings before and after rTMS sessions. Compared to sham, active rTMS significantly improved negative symptoms, irrespective of change in depressive symptoms.
重复经颅磁刺激（rTMS）对精神分裂症核心阳性和阴性症状的潜在影响尚未明确。本研究旨在采用双盲假对照设计，检验辅助性10赫兹阈上左侧前额叶rTMS对精神分裂症阴性症状的疗效。此外，我们的研究还探讨了将相同刺激条件应用于阳性症状的适用性。10名右利手精神分裂症患者接受了假刺激或10赫兹阈上rTMS对左侧背外侧前额叶皮层的刺激，并在rTMS治疗前后进行了精神病理学、抑郁和整体改善评分。与假刺激相比，无论抑郁症状有无变化，活性rTMS均能显著改善阴性症状。
