Huang Wanli, Shen Fang, Zhang Jiangtao, Xing Baoping
Tongde Hospital, Hangzhou, Zhejiang Province, China.
Shanghai Arch Psychiatry. 2016 Dec 25;28(6):309-317. doi: 10.11919/j.issn.1002-0829.216044.
The high smoking rate among patients with schizophrenia is an important public health problem, and researchers have been studying how to change the status quo.
We investigated the effects of high frequency (10Hz) repetitive transcranial magnetic stimulation on the amount of cigarette smoking in patients with schizophrenia.
This study enrolled 37 male patients with schizophrenia who were at a stable stage of treatment. Patients were randomly divided into a treatment group (n=19) and a control group (n=18). The treatment group received repetitive transcranial magnetic stimulation (rTMS) on the left prefrontal dorsolateral cortex (DLPFC), and the control group received placebo treatment. The number of cigarettes smoked were recorded at 7 days before treatment, during the course of treatment (i.e. for 21 days), and 3 weeks after treatment had ended. Assessments using the Positive and Negative Syndrome Scale (PANSS), Wisconsin Card Sorting Test (WCST), and Montgomery Asberg Depression Rating Scale (MADRS) were applied before and after treatment.
Compared to the control group, the number of cigarettes smoked in the treatment group showed a statistically significant reduction in the first week after treatment. However, there was no significant correlation between the scores on PANSS, WCST and MADRS and the number of cigarettes smoked before and after treatment in both groups.
High frequency (10Hz) repetitive transcranial magnetic stimulation on the left prefrontal cortex can reduce the number of cigarettes smoked in patients with schizophrenia.
精神分裂症患者的高吸烟率是一个重要的公共卫生问题，研究人员一直在研究如何改变这一现状。
我们研究了高频（10Hz）重复经颅磁刺激对精神分裂症患者吸烟量的影响。
本研究纳入了37名处于治疗稳定期的男性精神分裂症患者。患者被随机分为治疗组（n = 19）和对照组（n = 18）。治疗组接受左侧前额叶背外侧皮质（DLPFC）的重复经颅磁刺激（rTMS），对照组接受安慰剂治疗。在治疗前7天、治疗过程中（即21天）以及治疗结束后3周记录吸烟数量。在治疗前后使用阳性和阴性症状量表（PANSS）、威斯康星卡片分类测验（WCST）和蒙哥马利-艾斯伯格抑郁评定量表（MADRS）进行评估。
与对照组相比，治疗组在治疗后的第一周吸烟量有统计学意义的显著减少。然而，两组中PANSS、WCST和MADRS评分与治疗前后吸烟量之间均无显著相关性。
对左侧前额叶皮质进行高频（10Hz）重复经颅磁刺激可减少精神分裂症患者的吸烟量。
