Huh Jin Won, Kim Dong Soon, Oh Yeon-Mok, Shim Tae Sun, Lim Chae Man, Lee Sang Do, Koh Yunsuck, Kim Woo Sung, Kim Won Dong, Kim Kyu Rae
Division of Pulmonary and Critical Care Medicine, Asan Medical Center, College of Medicine, University of Ulsan, 388-1, Poongnap-dong, Songpa-gu, Seoul, Korea.
Chest. 2008 May;133(5):1101-6. doi: 10.1378/chest.07-2116. Epub 2007 Dec 10.
Matrix metalloproteinase (MMP)-7 was reported to be a key molecule in the pathogenesis of idiopathic pulmonary fibrosis (IPF) based on the result of microarray analysis and knockout mice. However, the role of MMP-7 has not been determined in other types of idiopathic interstitial pneumonia (IIP). The aim of this study was to investigate the role of MMP-7 in IIP by comparing its expression in usual interstitial pneumonia (UIP) and cryptogenic organizing pneumonia (COP).
Levels of MMP and tissue inhibitors of metalloproteinase in BAL fluid and their expression on lung tissues were compared between normal control subjects (n = 5) and the patients with IPF (n = 6) and COP (n = 11).
There was no significant difference in BAL fluid MMP-7 levels between UIP and COP, although it was higher in both diseases compared to normal control subjects. Furthermore, the pattern and the degree of MMP-7 expression in lung tissues were also similar in both IPF and COP, whereas MMP-2 level was higher in COP and MMP-9 level was higher in IPF.
MMP-7 seems to play an important role in the pathogenesis of not only IPF but also COP; therefore, it may not be the key factor determining the prognosis or reversibility of IIPs.
基于微阵列分析结果和基因敲除小鼠实验，基质金属蛋白酶（MMP）-7被报道为特发性肺纤维化（IPF）发病机制中的关键分子。然而，MMP-7在其他类型的特发性间质性肺炎（IIP）中的作用尚未明确。本研究旨在通过比较MMP-7在寻常型间质性肺炎（UIP）和隐源性机化性肺炎（COP）中的表达，探讨其在IIP中的作用。
比较正常对照组（n = 5）、IPF患者（n = 6）和COP患者（n = 11）支气管肺泡灌洗液（BALF）中MMP和金属蛋白酶组织抑制剂的水平及其在肺组织中的表达。
UIP和COP患者BALF中MMP-7水平无显著差异，尽管这两种疾病中的MMP-7水平均高于正常对照组。此外，IPF和COP患者肺组织中MMP-7的表达模式和程度也相似，而COP患者MMP-2水平较高，IPF患者MMP-9水平较高。
MMP-7似乎不仅在IPF的发病机制中起重要作用，在COP中也起重要作用；因此，它可能不是决定IIP预后或可逆性的关键因素。
