Jones Richard A, Schmotzer Brian, Little Stephen B, Grattan-Smith J Damien
Department of Radiology, Emory University School of Medicine/Children's Healthcare of Atlanta, 1001 Johnson Ferry Road, Atlanta, GA 30342, USA.
Pediatr Radiol. 2008 Jan;38 Suppl 1:S18-27. doi: 10.1007/s00247-007-0616-9. Epub 2007 Dec 11.
Dynamic magnetic resonance urography (MRU) scans acquired in conjunction with an injection of a contrast agent can be used to estimate a number of parameters that reflect renal function. This article discusses the methodologies and assumptions used in the estimation of these parameters, with special attention to the problem of deriving the concentration of the contrast agent from the change in the MR signal. The estimates of split renal function derived from MRU are in good agreement with those obtained using nuclear medicine studies. The time-intensity curves show subtle differences from those measured using nuclear medicine but still allow the transit of the contrast agent through the kidney to be assessed. Quantitative estimates of renal function (GFR) can be derived from MRU but have yet to be validated in a pediatric population.
结合注射造影剂进行的动态磁共振尿路造影（MRU）扫描可用于估计一些反映肾功能的参数。本文讨论了估计这些参数时所使用的方法和假设，特别关注从MR信号变化中推导造影剂浓度的问题。从MRU得出的分肾功能估计值与使用核医学研究获得的估计值高度一致。时间-强度曲线与使用核医学测量的曲线存在细微差异，但仍可用于评估造影剂在肾脏中的通过情况。肾功能（GFR）的定量估计值可从MRU得出，但尚未在儿科人群中得到验证。
