Murdin Louisa, Patel Sanjeev, Walmsley Josephine, Yeoh Lam Hoe
Department of Audiology, St Helier Hospital, Wrythe Lane, Carshalton, Surrey SM5 1AA, UK.
Clin Rheumatol. 2008 May;27(5):637-40. doi: 10.1007/s10067-007-0802-z. Epub 2007 Dec 11.
Rheumatoid arthritis (RA) is well known to affect many different organ systems. Previous work suggests that this includes the auditory system and that measures of hearing may be related to indices of RA disease activity. The aims of this study were to determine whether hearing loss in young subjects with rheumatoid arthritis is greater than would be expected in the normal population and whether disease activity or duration correlate with hearing levels. About 55 patients (less than 50 years old) with RA were sampled from a secondary-care-level population. Pure-tone audiograms, transient evoked otoacoustic emissions (TEOAEs) and rheumatological assessment including disease duration and the DAS28 disease activity score were carried out. Subjective hearing loss was a common symptom with a prevalence of 29.6% (95% CI 17.8-42.2%). The prevalence of conductive hearing loss was 1.9% (95% CI 0.3-9.7%)). Subjects with RA had worse hearing than expected at low and middle frequencies (250 Hz to 2 kHz). TEOAEs were absent in 15 of 84 (18%, 95% CI 11-27%) normal ears. No relationship was demonstrated between hearing thresholds and markers of disease activity or other rheumatological parameters. Hearing loss is common in young people with RA and should be sought by clinicians caring for this patient population. TEOAEs are absent in a higher proportion of patients than expected, and this may be a marker of early asymptomatic hearing loss. It may be conductive or sensorineural and may take any configuration, including low-frequency loss.
类风湿性关节炎(RA)会影响许多不同的器官系统,这是众所周知的。先前的研究表明,这其中包括听觉系统,且听力测量结果可能与RA疾病活动指数相关。本研究的目的是确定患有类风湿性关节炎的年轻受试者的听力损失是否大于正常人群的预期,以及疾病活动或病程是否与听力水平相关。从二级护理水平的人群中抽取了约55名(年龄小于50岁)患有RA的患者。进行了纯音听力图、瞬态诱发耳声发射(TEOAEs)以及包括病程和DAS28疾病活动评分在内的风湿病学评估。主观听力损失是一种常见症状,患病率为29.6%(95%置信区间17.8 - 42.2%)。传导性听力损失的患病率为1.9%(95%置信区间0.3 - 9.7%)。患有RA的受试者在低频和中频(250Hz至2kHz)的听力比预期更差。84只正常耳朵中有15只(18%,95%置信区间11 - 27%)未检测到TEOAEs。听力阈值与疾病活动标志物或其他风湿病学参数之间未显示出相关性。听力损失在患有RA的年轻人中很常见,诊治这类患者的临床医生应予以关注。未检测到TEOAEs的患者比例高于预期,这可能是早期无症状听力损失的一个标志。它可能是传导性或感音神经性的,可能呈现任何形式,包括低频损失。