Bianco V, Erba P, Remotti G
Cattedra di Patologia Ostetrica-Ginecologica, Università degli Studi di Milano.
Ann Ostet Ginecol Med Perinat. 1991 Jul-Aug;112(4):247-56.
The problem of warts' therapy is of great interest for the diffusion of this pathology, for its high rate of recurrence and for its relation to CIN. So we evaluated the efficacy of different therapeutic methods for vulvar condylomata, used in 254 patients treated in our center from January '86 to July '90. 55 women underwent hot cautery, 31 laser-therapy, 42 excisional biopsy, 62 were treated with alpha interferon, 11 with beta interferon, 13 with thymopentin in association with electro-cautery or laser and in 40 cases no treatment was performed. The follow up, from 6 to 36 months, showed a remission of 88.1% in excisional biopsy, of 77.4% in laser-therapy, of 70.9% in electro-cautery, of 45.4% in beta interferon, of 45.2% in alpha interferon, of 76.9% in thymopentin and of 65% in the not treated group. No one therapy yielded optimal results, although surgical methods appeared to allow complete removal of the wart lesion with one application only, and to be better accepted by the patients because of the psychologic benefit of immediate remission notwithstanding the possibility of recurrencies. The results of the studied medical therapies appeared scanty. We conclude that, being the tissues around florid lesion purely affected by HPV, medical therapy needs further research in the hope of a more radical treatment.
由于疣这种病症的广泛传播、高复发率以及它与宫颈上皮内瘤变（CIN）的关系，疣的治疗问题备受关注。因此，我们评估了不同治疗方法对外阴尖锐湿疣的疗效，这些方法应用于1986年1月至1990年7月在我们中心接受治疗的254例患者。55名女性接受了热烧灼治疗，31名接受了激光治疗，42名接受了切除活检，62名接受了α干扰素治疗，11名接受了β干扰素治疗，13名接受了胸腺五肽联合电烧灼或激光治疗，40例未进行治疗。6至36个月的随访显示，切除活检的缓解率为88.1%，激光治疗为77.4%，电烧灼为70.9%，β干扰素为45.4%，α干扰素为45.2%，胸腺五肽为76.9%，未治疗组为65%。尽管手术方法似乎仅通过一次治疗就能完全去除疣体病变，并且由于能立即缓解带来心理益处，尽管存在复发可能性，但患者更容易接受，但没有一种治疗方法能产生最佳效果。所研究的药物治疗结果似乎不太理想。我们得出结论，鉴于活跃病变周围的组织仅受人乳头瘤病毒（HPV）影响，药物治疗需要进一步研究，以期找到更彻底的治疗方法。
