Piccoli R, Santoro M G, Nappi C, Capodanno M, De Santis V, La Torre P C, Costa S, Montemagno U
Department of Gynaecology Obstetrics and Physiopathology of Human Reproduction II Faculty of Medicine, University of Naples, Italy.
Clin Exp Obstet Gynecol. 1989;16(1):30-5.
The therapeutical effectiveness of beta-interferon and the possibility of reducing the incidence of relapses were evaluated by selecting three groups of patients affected with three forms of condylomatosis and submitting then to various treatments. In the first group of sixty patients treated with beta-interferon, we obtained the best results in micro-condylomatosis (a 100% response), while florid condylomatosis responded less well to the treatment (72% with no response). In the second group of ten patients, electrocoagulation of florid condylomata determined a complete response (CR) in seven cases (70%). Moreover, immunoperoxidase identified three case of sub-clinical infection, two of which relapsed. In the third group of ten patients, we combined electrocoagulation with beta-interferon. This combination showed the effectiveness of beta-interferon in decreasing relapses. This result is evident if we consider that only one out of four patients with immunoperoxidase-positive biopsy relapsed.
通过选择三组患有三种尖锐湿疣形式的患者并对其进行不同治疗，评估了β-干扰素的治疗效果以及降低复发率的可能性。在第一组接受β-干扰素治疗的60名患者中，我们在微小尖锐湿疣（100%有反应）中取得了最佳效果，而尖锐湿疣活跃期对该治疗的反应较差（72%无反应）。在第二组10名患者中，尖锐湿疣活跃期的电凝治疗在7例（70%）中产生了完全缓解（CR）。此外，免疫过氧化物酶检测出3例亚临床感染，其中2例复发。在第三组10名患者中，我们将电凝与β-干扰素联合使用。这种联合显示了β-干扰素在减少复发方面的有效性。如果我们考虑到免疫过氧化物酶活检阳性的患者中只有四分之一复发，这一结果就很明显了。
