保守的A16Leu对胰岛素可折叠性的贡献。
Contribution of the conserved A16Leu to insulin foldability.
作者信息
Zhang Zhao-Jun, Wu Lan, Qiao Zhi-Song, Qiao Ming-Qiang, Feng You-Min, Guo Zhan-Yun
机构信息
Institute of Molecular Biology, College of Life Sciences, Nan Kai University, Tian Jin 300071, China.
出版信息
Protein J. 2008 Apr;27(3):192-6. doi: 10.1007/s10930-007-9124-x.
PMID:18071885
Abstract
Contributions of the evolutionarily conserved A16Leu and B17Leu to insulin foldability were characterized by evaluating folding properties of single-chain insulin analogs. The results showed A16Leu had much more significant effects on the foldability of insulin than B17Leu.
摘要
通过评估单链胰岛素类似物的折叠特性，对进化保守的A16Leu和B17Leu对胰岛素可折叠性的贡献进行了表征。结果表明，A16Leu对胰岛素可折叠性的影响比B17Leu更为显著。
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