Thompson Trevonne M, Aks Steven E
The Toxikon Consortium, Department of Emergency Medicine, University of Illinois at Chicago, Chicago, IL, USA.
J Med Toxicol. 2007 Mar;3(1):31-6. doi: 10.1007/BF03161036.
Suicide attempts by health care workers are very serious because these patients have the knowledge of and access to potentially lethal substances. Our patient presented with hypotension and hemodynamic instablility. He was treated with multiple-dose activated charcoal and 2 rounds of hemodialysis. While there was rapid toxicokinetic improvement and extubation on day 2 of his hospital stay, he had prolonged altered mental status, illustrating the long-acting effects of phenobarbital. It remains unclear exactly how our medical treatment regimens alter the clinical course of phenobarbital poisoning. We are indebted to Clemmesen and Nilsson for their description of the Scandinavian Method and the resulting reduction in morbidity from sedative-hypnotic poisoning. Further research is needed to define the precise clinical benefit achieved from additional therapeutic modalities in treating such poisonings.
医护人员的自杀未遂事件非常严重，因为这些患者了解并能够获取潜在的致命物质。我们的患者出现了低血压和血流动力学不稳定的症状。他接受了多剂量活性炭治疗和两轮血液透析。虽然在住院第2天其毒代动力学迅速改善且拔除了气管插管，但他的精神状态改变持续了很长时间，这说明了苯巴比妥的长效作用。目前尚不清楚我们的治疗方案究竟如何改变苯巴比妥中毒的临床病程。我们感谢克莱默森和尼尔森对斯堪的纳维亚方法的描述以及由此降低的镇静催眠药中毒发病率。需要进一步研究来确定在治疗此类中毒时其他治疗方式所带来的精确临床益处。
