Goldberg M J, Berlinger W G
JAMA. 1982 May 7;247(17):2400-1.
Patients with phenobarbital overdose who are treated only with supportive care may remain comatose for several days because of the long elimination half-life of phenobarbital. We treated two patients with phenobarbital overdoses with the nasogastric administration of multiple doses of activated charcoal. This safe therapy markedly shortened both the elimination half-life of phenobarbital and the duration of coma in these patients. If all such patients respond similarly, we believe that the nasogastric administration of multiple doses of activated charcoal is the method of choice to accelerate the elimination of phenobarbital from the body.
仅接受支持性治疗的苯巴比妥过量患者可能会因苯巴比妥较长的消除半衰期而昏迷数天。我们对两名苯巴比妥过量患者进行了多次经鼻胃管给予活性炭的治疗。这种安全的治疗方法显著缩短了这些患者体内苯巴比妥的消除半衰期和昏迷持续时间。如果所有此类患者都有类似反应，我们认为多次经鼻胃管给予活性炭是加速苯巴比妥从体内消除的首选方法。
