Ekele B A, Nnadi D C, Gana M A, Shehu C E, Ahmed Y, Nwobodo E I
Department of Obstetrics and Gynaecology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.
Niger J Clin Pract. 2007 Sep;10(3):234-7.
Induction of labor is always a challenge to many an obstetrician more so when the cervix is unfavorable.
To determine the efficacy and safety ofmisoprostol in cervical ripening and labour induction.
Aprospective study spanning 2 years and involving 151 patients admitted for cervical ripening and induction of labor at Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. 50 microgram (mcg) ofmisoprostol was inserted vaginally every 4 hours until cervix became favorable or onset of labor.
Main indications for induction of labour were prolonged pregnancy and hypertensive diseases of pregnancy. An average of 2 insertions of 50 mcg tablet was used to achieve cervical ripening in 107 patients (71%) and 80% (120) had spontaneous labor within 10 hours of insertion. The mean insertion-labor interval was 7.86 hours (SD +/- 2.5). The average duration of labour was 9.36 hours (SD +/- 2.9). Vaginal delivery was achieved in 96% of the patients. Uterine hyperstimulation occurred in 9 patients but there was no case of uterine rupture.
Misoprostol was effective and safe in cervical ripening and induction of labor with a vaginal delivery rate of 96%. It should be an essential drug in obstetric practice especially in low resource settings.
引产对许多产科医生来说始终是一项挑战，尤其是在宫颈条件不佳时。
确定米索前列醇在宫颈成熟和引产方面的有效性和安全性。
一项为期2年的前瞻性研究，纳入了在尼日利亚索科托的乌斯曼努·丹福迪奥大学教学医院因宫颈成熟和引产入院的151例患者。每4小时经阴道置入50微克米索前列醇，直至宫颈条件改善或临产。
引产的主要指征为过期妊娠和妊娠高血压疾病。107例患者（71%）平均使用2次50微克片剂实现了宫颈成熟，80%（120例）在置入后10小时内自然临产。置入至临产的平均间隔时间为7.86小时（标准差±2.5）。平均产程为9.36小时（标准差±2.9）。96%的患者实现了阴道分娩。9例患者出现子宫过度刺激，但无子宫破裂病例。
米索前列醇在宫颈成熟和引产方面有效且安全，阴道分娩率为96%。它应成为产科实践中的基本药物，尤其是在资源匮乏地区。
