Corsi Alessandro, De Maio Fernando, Mancini Federico, Ippolito Ernesto, Riminucci Mara, Bianco Paolo
Dipartimento di Medicina Sperimentale, Università La Sapienza, Rome, Italy.
J Bone Miner Res. 2008 Apr;23(4):572-5. doi: 10.1359/jbmr.071204.
Nontumoral notochordal inclusions in vertebral bone marrow give rise to MRI-detectable lesion without osteolysis, and their detection may cause concern or overtreatment. These lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment. We present a case of nontumoral notochordal inclusions in vertebral bone marrow, giving rise to an MRI detectable lesion without osteolysis. MRI detection of such lesions may cause concern or overtreatment. Quite distinct from chordomas, these lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment.
椎骨髓中的非肿瘤性脊索包涵体可产生MRI可检测到的病变而无骨质溶解，其检测可能引起担忧或过度治疗。这些病变可能源于生命早期脊索细胞从髓核脱位，随后在适宜的骨髓微环境中生长。我们报告一例椎骨髓中的非肿瘤性脊索包涵体，产生了MRI可检测到的无骨质溶解的病变。MRI检测到此类病变可能引起担忧或过度治疗。与脊索瘤截然不同，这些病变可能源于生命早期脊索细胞从髓核脱位，随后在适宜的骨髓微环境中生长。
