Wouters Emiel F M, Groenewegen Karin H, Dentener Mieke A, Vernooy Juanita H J
Department of Respiratory Medicine, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Proc Am Thorac Soc. 2007 Dec;4(8):626-34. doi: 10.1513/pats.200706-071TH.
The systemic manifestations of chronic obstructive pulmonary disease (COPD) exacerbations are recognized, but our understanding of their etiology and importance is lacking largely due to the small number of systematic and longitudinal studies. Most of the systemic manifestations are likely the result of inflammatory processes. Serum biomarkers, such as various cytokines, adipokines, C-reactive protein, and coagulation factors, are elevated during exacerbations. Our understanding of the systemic manifestations can be greatly enhanced if we integrate what is known about the basic science of systemic mediators with the translational science of their role in COPD exacerbations. Many overlapping connections and promising avenues of future research come to light with such a viewpoint.
慢性阻塞性肺疾病（COPD）急性加重的全身表现已得到公认，但由于系统性和纵向研究数量较少，我们对其病因及重要性的了解仍很欠缺。大多数全身表现可能是炎症过程的结果。在急性加重期间，血清生物标志物如各种细胞因子、脂肪因子、C反应蛋白和凝血因子会升高。如果我们将关于全身介质基础科学的已知知识与它们在COPD急性加重中作用的转化科学相结合，就能大大增进我们对全身表现的理解。从这样的观点来看，许多重叠的联系和未来研究的有前景途径便会显现出来。
