Department of Respiratory Medicine, Maastricht University Medical Centre+, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
Respir Med. 2011 Jul;105(7):1046-53. doi: 10.1016/j.rmed.2011.02.001. Epub 2011 Mar 1.
COPD is characterized by a multi-component character involving a state of low-grade systemic inflammation and an increased prevalence of cardiovascular co-morbidity. The role of circulating leptin and other adipokines in the involvement of the systemic inflammation in COPD is only studied scarcely.
To investigate gender related differences in the adipokine metabolism in relation to systemic inflammatory biomarkers in clinically stable subjects with COPD.
In total, 91 clinically stable COPD patients and 35 healthy control subjects, matched for body mass index (BMI) with the COPD subjects, were included. Lung function measurement and body composition were performed in patients with COPD. In the total group, plasma concentration of the adipokines (leptin, adiponectin and resistin) and systemic inflammatory biomarkers C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor α (TNFα), and its soluble receptors 55 and 75 (sTNFα-R55, R75) were analyzed.
The COPD group was characterized by increased levels of CRP, IL-6 and leptin. Plasma adiponectin and resistin concentrations were not different between the COPD and the control group. Within the COPD group, there was a significant interaction between gender and BMI on the leptin/fat mass ratio. In COPD women, a significant correlation between leptin and CRP was present.
In men with clinically stable COPD, leptin, adiponectin and resistin appear to be physiologically regulated, while in women, leptin metabolism is altered. Leptin secretion is increased in COPD women when compared to healthy women and compared to COPD men, and to a greater extent in overweight women with COPD.
COPD 的特征是多组分特征，涉及低度全身炎症状态和心血管共病患病率增加。循环瘦素和其他脂肪因子在 COPD 全身炎症中的作用仅得到很少的研究。
研究性别相关的差异在与 COPD 患者的全身炎症生物标志物相关的脂肪因子代谢中的作用。
共纳入 91 例临床稳定的 COPD 患者和 35 例健康对照者，这些对照者与 COPD 患者的体重指数（BMI）相匹配。对 COPD 患者进行肺功能测量和身体成分检查。在总人群中，分析了脂肪因子（瘦素、脂联素和抵抗素）和全身炎症生物标志物 C 反应蛋白（CRP）、白细胞介素 6（IL-6）、肿瘤坏死因子 α（TNFα）及其可溶性受体 55 和 75（sTNFα-R55、R75）的血浆浓度。
COPD 组的 CRP、IL-6 和瘦素水平升高。COPD 组和对照组的血浆脂联素和抵抗素浓度无差异。在 COPD 组中，性别和 BMI 之间存在瘦素/脂肪量比值的显著相互作用。在 COPD 女性中，瘦素与 CRP 之间存在显著相关性。
在临床稳定的 COPD 男性中，瘦素、脂联素和抵抗素似乎是生理性调节的，而在女性中，瘦素代谢发生改变。与健康女性和 COPD 男性相比，COPD 女性的瘦素分泌增加，超重的 COPD 女性增加幅度更大。
