蛋白酶体功能的代谢调控
Metabolic control of proteasome function.
作者信息
Zhang Fengxue, Paterson Andrew J, Huang Ping, Wang Kai, Kudlow Jeffrey E
机构信息
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, USA.
出版信息
Physiology (Bethesda). 2007 Dec;22:373-9. doi: 10.1152/physiol.00026.2007.
PMID:18073410
Abstract
Proteasomes are major cellular proteases that are important for protein turnover and cell survival. Dysregulation of proteasome is related to many major human diseases. Regulation of the proteasome is beginning to be understood by the recent findings that proteasomes are modified and regulated by metabolic factors O-GlcNAcylation and PKA phosphorylation.
摘要
蛋白酶体是主要的细胞蛋白酶，对蛋白质周转和细胞存活至关重要。蛋白酶体失调与许多主要人类疾病相关。最近的研究发现蛋白酶体受到代谢因子O-连接的N-乙酰葡糖胺化和蛋白激酶A磷酸化的修饰和调节，人们由此开始了解蛋白酶体的调控机制。
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