Luciano A A, Metzger D A
Division of Reproductive Endocrinology, University of Connecticut School of Medicine, Farmington.
Br J Clin Pract Suppl. 1991 Autumn;72:14-23; discussion 24-6.
Endometriosis is often debilitating and can adversely affect fertility. Medical management has largely consisted of hormonal therapy, employing the entire spectrum of sex steroids, singly or in combination, and has primarily aimed to relieve pain and increase conception rates. Recently the efficacy of such treatment has been called into question. The current status of the hormonal therapy of endometriosis is critically reviewed, with sufficient historical background and summaries of clinical trials to allow interpretation of the available data. The impact of hormonal therapy on the cause and the natural history of disease is also assessed. Finally, recommendations regarding therapy, along with necessary directions for future clinical studies, are presented.
子宫内膜异位症常常使人虚弱，会对生育能力产生不利影响。药物治疗主要包括激素疗法，使用了全谱性类固醇，单独使用或联合使用，主要目的是缓解疼痛并提高受孕率。最近，这种治疗方法的疗效受到了质疑。本文对子宫内膜异位症激素治疗的现状进行了批判性综述，提供了充分的历史背景和临床试验总结，以便对现有数据进行解读。还评估了激素治疗对疾病病因和自然病程的影响。最后，提出了关于治疗的建议以及未来临床研究的必要方向。
