Olive David L
Department of Obstetrics and Gynecology, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792-6188, USA.
Semin Reprod Med. 2003 May;21(2):209-22. doi: 10.1055/s-2003-41327.
The medical treatment of endometriosis is a critical aspect of the therapeutic approach to this disease. Past methods have been based upon systemic hormonal alterations, resulting in suppression of this estrogen-responsive disorder. Treatments such as danazol, progestogens, oral contraceptives, GnRH-agonists, and gestrinone achieve their effects upon endometriosis via this method. However, with a growing understanding of the pathogenesis of this disease, more precise molecular targets for treatment have been identified. Thus, a series of newer agents are under development and hold the potential of greater efficacy and flexibility than traditional treatments. This review analyzes the available and experimental medical treatments of endometriosis, their utility in the treatment of pain and infertility, and their role in the future.
子宫内膜异位症的药物治疗是该疾病治疗方法的关键环节。过去的方法基于全身性激素改变，从而抑制这种雌激素反应性疾病。诸如达那唑、孕激素、口服避孕药、促性腺激素释放激素激动剂和孕三烯酮等治疗方法通过这种方式对子宫内膜异位症产生作用。然而，随着对该疾病发病机制的认识不断深入，已确定了更精确的治疗分子靶点。因此，一系列更新的药物正在研发中，与传统治疗方法相比，它们具有更高疗效和更大灵活性的潜力。这篇综述分析了现有的以及实验性的子宫内膜异位症药物治疗方法、它们在治疗疼痛和不孕症方面的效用以及它们在未来的作用。
