Lim D Y, Lee K J, Kim S H, Kim B H, Lee J J, Lee E H, Chang K S, Hong S P
Department of Pharmacology and Internal Medicine, Chosun University Medical College, Kwang Joo, Korea.
Korean J Intern Med. 1991 Jul;6(2):69-78. doi: 10.3904/kjim.1991.6.2.69.
The influence of amineptine, an antidepressant currently employed having mainly selective dopaminergic neurochemical activity, on the pressor responses evoked by norepinephrine (NE) and dopamine (DA) was studied in anesthetized whole rats. Amineptine at doses of 0.5, 1.5, and 5.0 mg/kg/30 min infused into the femoral vein of the rat caused a dose-related inhibition of the pressor responses of NE and DA. The hypertensive responses of NE and DA augmented by pretreatment with reserpine, a catecholamine depletor, were also clearly depressed following the infusion of amineptine with a rate of 1.5 mg/kg/30 min. Furthermore, the pressor responses of NE and DA potentiated by pretreatment with debrisoquin, a sympathetic neuron blocker, were markedly diminished after pretreatment with the infusion of amineptine at the above same rate (1.5 mg/kg/30 min). These experimental results demonstrate that amineptine causes an inhibitory effect on the pressor responses evoked by NE and DA. It is thought that the amineptine effect may be due to the blockade of the peripheral adrenergic alpha-receptors in addition to the previously described uptake inhibition of dopamine.
研究了目前使用的主要具有选择性多巴胺能神经化学活性的抗抑郁药安咪奈丁对麻醉的完整大鼠中去甲肾上腺素（NE）和多巴胺（DA）诱发的升压反应的影响。以0.5、1.5和5.0mg/kg/30min的剂量将安咪奈丁注入大鼠股静脉，可引起与剂量相关的对NE和DA升压反应的抑制。用儿茶酚胺耗竭剂利血平预处理增强的NE和DA的高血压反应，在以1.5mg/kg/30min的速率注入安咪奈丁后也明显受到抑制。此外，用交感神经神经元阻滞剂地布喹预处理增强的NE和DA的升压反应，在以相同速率（1.5mg/kg/30min）注入安咪奈丁预处理后明显减弱。这些实验结果表明，安咪奈丁对NE和DA诱发的升压反应有抑制作用。据认为，安咪奈丁的作用可能是由于除了先前描述的对多巴胺的摄取抑制外，还阻断了外周肾上腺素能α受体。
