阿米替林：其对大鼠多巴胺能系统的影响。

Amineptine: its effect on the dopaminergic system of rats.

作者信息

Ponzio F, Achilli G, Garattini S, Perego C, Sacchetti G, Algeri S

出版信息

J Pharm Pharmacol. 1986 Apr;38(4):301-3. doi: 10.1111/j.2042-7158.1986.tb04572.x.

DOI:10.1111/j.2042-7158.1986.tb04572.x

Abstract

3-Methoxytyramine formation was enhanced by amineptine (40 mg kg-1 i.p.) in the striatum and limbic area, indicating an increase in the concentration of dopamine in the extraneuronal space. Since dopamine turnover, determined as the rate of L-dopa accumulation, is reduced by the drug at short (10 min) times, the enhanced extraneuronal dopamine concentration seems mainly related to amineptine-induced inhibition of its uptake.

摘要

在纹状体和边缘区域，胺苯环庚烯（腹腔注射40毫克/千克）可增强3-甲氧基酪胺的生成，这表明细胞外空间中多巴胺浓度增加。由于以左旋多巴积累速率测定的多巴胺周转率在短时间（10分钟）内会被该药物降低，细胞外多巴胺浓度的增加似乎主要与胺苯环庚烯诱导的多巴胺摄取抑制有关。