Effective point-spread function for fast image modeling and processing in microscopic imaging through turbid media.

An effective point-spread function (EPSF) for microscopic imaging through turbid media is proposed and calculated. The EPSF incorporates the property of a microscope system as well as the scattering property of a turbid medium. We prove that the image of a thin object embedded in a turbid medium can be expressed by the convolution of the EPSF with an object function. With the help of the convolution relation, image modeling for 5, 000, 000 incident photons can be approximately 15 times faster than the direct Monte Carlo simulation method for a one-dimensional object and can be at least 2 orders of magnitude faster for a two-dimensional object.