Millington D S, Golder M P, Cowley T, London D, Roberts H, Butt W R, Griffiths K
Acta Endocrinol (Copenh). 1976 Jul;82(3):561-71. doi: 10.1530/acta.0.0820561.
The study describes the effects of ACTH, prolactin and other protein hormones on the synthesis and secretion of steroid hormones by tissue from a feminising adrenocortical carcinoma removed from a post-menopausal female. Steroid production by the tissue was determined by high resolution-mass fragmentography and by radioimmunoassay. Prolactin and ACTH stimulated the synthesis of estrogens by the tissue whereas GH, LH and ACTH were more effective than prolactin in stimulating androgen synthesis. The effect of protein hormones, other than ACTH, on adenylate cyclase activity of this tumour tissue indicated a lack of specificity of the membrane receptor sites.
该研究描述了促肾上腺皮质激素、催乳素和其他蛋白质激素对一名绝经后女性切除的女性化肾上腺皮质癌组织中类固醇激素合成和分泌的影响。通过高分辨率质谱碎片分析法和放射免疫分析法测定该组织的类固醇生成。催乳素和促肾上腺皮质激素刺激该组织合成雌激素，而生长激素、促黄体生成素和促肾上腺皮质激素在刺激雄激素合成方面比催乳素更有效。除促肾上腺皮质激素外，其他蛋白质激素对该肿瘤组织腺苷酸环化酶活性的影响表明膜受体位点缺乏特异性。
