James Dominic, Parone Philippe A, Terradillos Olivier, Lucken-Ardjomande Safa, Montessuit Sylvie, Martinou Jean-Claude
Department of Cell Biology, University of Geneva, Quai Ernest-Ansermet 30, Geneva, Switzerland.
Novartis Found Symp. 2007;287:170-6; discussion 176-82.
In response to many apoptotic stimuli, Bcl-2 family pro-apoptotic members, such as Bax and Bak, are activated. This results in their oligomerization, permeabilization of the outer mitochondrial membrane, and release of many proteins that are normally confined in the mitochondrial inter-membrane space. Among these proteins are cytochrome c, Smac/DIABLO, OMI/HtrA2, AIF and endonuclease G. Mitochondrial outer membrane permeabilization (MOMP) is also associated with fragmentation of the mitochondrial network. The mechanisms that lead to the oligomerization of proapoptotic members of the Bcl-2 family and to MOMP are still unclear and the role of mitochondrial fission in these events remains elusive.
响应多种凋亡刺激时，Bcl-2家族促凋亡成员，如Bax和Bak，会被激活。这导致它们寡聚化、线粒体外膜通透性增加，并释放许多通常局限于线粒体膜间隙的蛋白质。这些蛋白质包括细胞色素c、Smac/DIABLO、OMI/HtrA2、AIF和核酸内切酶G。线粒体外膜通透性增加（MOMP）也与线粒体网络的碎片化有关。导致Bcl-2家族促凋亡成员寡聚化以及MOMP的机制仍不清楚，线粒体分裂在这些事件中的作用也仍然难以捉摸。
