Davydova S M, Idova G V
Ross Fiziol Zh Im I M Sechenova. 2007 Oct;93(10):1156-62.
It is shown that a selective agonist of 5-HT1A receptors 8-OH-DPAT in a low dose (0.1 mg/kg), which is known to affect mainly the presynaptic 5-HT1A receptors increased the immune response at the peak of reactions (the forth or fifth day after immunization with sheep red blood cells - SRBC) in CBA mice and Wistar rats. Treatment of the animals with the drug 15 min prior to antigen injection raised the number of plaque-forming cells (lgM-PFC) and rosette-forming cells (RFC) in the spleen. The preliminary blockade of 5-HT1A receptor with a selective antagonist of 5-HT1A receptors WAY-100635 (0.1 mg/kg) prevented the immunostimulating effect of 5-HT 1A receptors agonist 8-OH-DPAT, whereas WAY-100635 administration alone in the same dose didn't change the immune response. Activation of 5-HT1A receptors under conditions of electrical lesion of 5-HTergic neurons of the nucleus raphe was unable to enhance the immune reactions, as it did in sham-operated rats. The data obtained indicate that the somatodendric 5-HT1A autoreceptors are involved in immunomodulation.
研究表明，5-HT1A受体的选择性激动剂8-OH-DPAT在低剂量（0.1毫克/千克）时，主要影响突触前5-HT1A受体，可增强CBA小鼠和Wistar大鼠在反应高峰期（用绵羊红细胞-SRBC免疫后的第四天或第五天）的免疫反应。在注射抗原前15分钟用该药物处理动物，可增加脾脏中形成斑块的细胞（lgM-PFC）和形成玫瑰花结的细胞（RFC）的数量。用5-HT1A受体的选择性拮抗剂WAY-100635（0.1毫克/千克）预先阻断5-HT1A受体，可阻止5-HT1A受体激动剂8-OH-DPAT的免疫刺激作用，而单独给予相同剂量的WAY-100635则不会改变免疫反应。在中缝核5-羟色胺能神经元电损伤的情况下，激活5-HT1A受体无法增强免疫反应，而在假手术大鼠中则可以。所获得的数据表明，树突体5-HT1A自身受体参与免疫调节。
