[果胶酸钙抗溃疡活性的实验评估]

[Experimental evaluation of the antiulcer activity of calcium pectate].

作者信息

Krylova S G, Efimova L A, Zueva E P, Khotimchenko M Iu, Razina T G, Amosova E N, Lopatina K A, Khotimchenko Iu S

出版信息

Eksp Klin Farmakol. 2007 Sep-Oct;70(5):19-23.

Abstract

Both chronic (prophylactic) and single administration of standardized calcium pectate considerably increased the resistance of rat stomach mucous membrane with respect to ulcerogenic factors of various etiology, including immobilized stress, indomethacin, ethanol, prednizolone, and histamine, according to H. Shay's model. The gastroprotective effect of this polysaccharide was comparable with or exceeded the action of famotidine, sea buckthorn oil, and maalox.

摘要

根据H. Shay模型，长期（预防性）和单次给予标准化果胶钙均可显著提高大鼠胃黏膜对多种病因致溃疡因素的抵抗力，这些因素包括固定应激、消炎痛、乙醇、泼尼松龙和组胺。这种多糖的胃保护作用与法莫替丁、沙棘油和氢氧化铝镁的作用相当或更强。