Deviatkina T A, Vazhnichaia E M, Oleĭnik N A
Eksp Klin Farmakol. 2007 Sep-Oct;70(5):24-6.
Experiments on a group of 39 Wistar albino male rats showed that, 2 and 5 days after a model acute stress procedure, the total amount of erythrocytes is increased. This process is accompanied by a hypochromia of red cells and by a decrease in the concentration of serum iron. Single administration of mexidol (100 mg/kg) before stress induction prevents changes in the amount of blood erythrocytes, as well as in their saturation with hemoglobin. Mexidol also prevents a decrease in the level of serum iron. The drug does not influence the hematological parameters and iron concentration in blood serum of intact animals 2 and 5 days after injection.
对一组39只Wistar白化雄性大鼠进行的实验表明，在急性应激模型程序后的第2天和第5天，红细胞总数增加。这一过程伴随着红细胞低色素血症和血清铁浓度降低。在应激诱导前单次给予美西多（100mg/kg）可防止血液红细胞数量及其血红蛋白饱和度的变化。美西多还可防止血清铁水平降低。该药物在注射后第2天和第5天对未受影响动物的血液学参数和血清铁浓度没有影响。
