美西多宁对谷氨酸应激细胞模型的神经保护作用研究
[A study of the neuroprotective effect of mexidol on the cell model of glutamate stress].
作者信息
Gromova O A, Torshin I Yu, Stelmashuk E V, Alexandrova O P, Pronin A V, Gogoleva I V, Haspekov L G
机构信息
Federal Research Center 'Informatics and Cybernetics', RAS, Moscow, Russia.
Scientific Center of Neurology, Moscow, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(12):71-77. doi: 10.17116/jnevro201711712171-77.
AIM
To study a neuroprotective effect of mexidol on the cell model of glutamate stress.
MATERIAL AND METHODS
Cytological studies of an effect of glutamate stress on cerebellar granule cells were carried out.
RESULTS
Mexidol increased neuronal survival after the addition of glutamate by 8-10% (p<0.05). The effect of mexidol was more pronounced at the stage of neuron culture growth (5 days), cell survivability increased on average by 20%.
CONCLUSION
The results of the study confirmed the neuroprotective effect of mexidol in the neuronal culture in glutamate toxicity model.
目的
研究美西律对谷氨酸应激细胞模型的神经保护作用。
材料与方法
对谷氨酸应激对小脑颗粒细胞的影响进行细胞学研究。
结果
添加谷氨酸后，美西律使神经元存活率提高了8 - 10%（p<0.05）。美西律在神经元培养生长阶段（5天）的作用更为显著，细胞存活率平均提高了20%。
结论
该研究结果证实了美西律在谷氨酸毒性模型的神经元培养中具有神经保护作用。
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