[Suppression of immune response associated with functions of B-cells, Th1- and Th2-lymphocytes and interleukins produced by these cells, and pharmacological correction of these disturbances upon acute intoxication with methanol].

Experiments on Wistar rats showed that acute poisoning with methanol (0.75 LD50) leads to the suppression of cellular and humoral immune responses and decreases the blood concentration of interleukins (IL-2, IL-4) with an increase in the IL-2/IL-4 ratio. These facts indicate that a decrease in Th2 lymphocyte activity is more pronounced in comparison to that of Th1 cells. The immunomodulators mielopide and polyoxidon administered in a daily dose of 10 mg/kg for 4 days upon acute poisoning with methanol virtually completely restore the cellular and humoral immune responses, the activity of natural killers, and the synthesis of interleukins.