M胆碱受体在Th1和Th2淋巴细胞功能调节中的作用
[The role of M-cholinoreceptors in the regulation of Th1 and Th2 lymphocyte functions].
作者信息
Zabrodskiĭ P F, Germanchuk V G, Mandych V G
出版信息
Eksp Klin Farmakol. 2008 Mar-Apr;71(2):47-9.
PMID:18488908
Abstract
Experiments on Wistar rats showed that the activation of m-cholinoreceptors by aceclidine (daily administration in a dose of 0.05 LD50, s.c., for 3 days) enhanced the function of Th1 lymphocytes to a greater extent in comparison to Th2 lymphocytes. The blockage of m-cholinoreceptors by the atropin led to a more pronounced suppression of Th2 lymphocytes function in comparison to Th1 cells.
摘要
对Wistar大鼠进行的实验表明，醋克利定（以0.05 LD50的剂量皮下注射，每日一次，共3天）激活M胆碱受体后，与Th2淋巴细胞相比，Th1淋巴细胞的功能增强更为显著。与Th1细胞相比，阿托品阻断M胆碱受体导致Th2淋巴细胞功能受到更明显的抑制。
Zotero 插件