Wang H L, Somerman M J
Department of Periodontics/Prevention and Geriatrics, University of Michigan School of Dentistry, Ann Arbor.
Curr Opin Dent. 1991 Dec;1(6):816-25.
Connective tissues of the periodontium are composed of cells and their related extracellular matrix components. For these tissues to respond appropriately during development and regeneration as well as in health, a precise regulation of cell-cell interactions and cell-substrata interactions must occur. Thus, in order to achieve more predictable clinical results, it is critical that the mechanisms and proteins and factors guiding tissue development, maintenance, and regeneration be understood at the cellular and molecular level. This has resulted in an increased emphasis on identifying components of the periodontium and subsequently determining how these proteins and factors regulate cell behavior. This review summarizes our current knowledge of the proteins and factors considered important to development, maintenance, and regeneration of periodontal tissues.
牙周组织的结缔组织由细胞及其相关的细胞外基质成分组成。为了使这些组织在发育、再生以及健康状态下能做出适当反应，必须精确调节细胞间相互作用和细胞与基质间的相互作用。因此，为了获得更可预测的临床结果，至关重要的是在细胞和分子水平上理解指导组织发育、维持和再生的机制、蛋白质和因子。这导致人们更加重视识别牙周组织的成分，并随后确定这些蛋白质和因子如何调节细胞行为。本综述总结了我们目前对牙周组织发育、维持和再生中重要的蛋白质和因子的认识。
