Reddy T P K, Reddy K K, Reddy P G
Instituto de Genética, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Puerta 7, Nivel II, 950 Sierra Mojada, Col. Independencia, Guadalajara, Jalisco 44340, Mexico.
Hum Biol. 2007 Aug;79(4):413-25. doi: 10.1353/hub.2007.0052.
Consanguineous marriages have been practiced around the globe by many societies from time immemorial, particularly in South India. Consanguineous marriages play a major role in the health of a population, and diseases leading to mortality of the progeny are a consequence of detrimental recessive genes. To evaluate the effects of ancestral consanguinity on mortality in relation to consanguineous marriage, we have ascertained data from 1,500 women belonging to three endogamous communities (Akuthota Reddy, Odde, and Madiga) of Chittoor District, Andhra Pradesh, India. There were 500 women from each community. For each marriage we drew a family pedigree, extended upward to two earlier generations on either side of the spouses, to determine the prevalence and pattern of consanguinity, with detailed information on fertility and mortality. We observed a significant difference in the mortality rates between consanguineous and nonconsanguineous marriages when all the marriages of the women, women's parents, and (women's) husband's parents were considered in all three communities. In inbreeding, the offspring of earlier generations might have passed on deleterious genes to later generations (under unfavorable conditions), which resulted in a negative aspect of reproduction (among the offspring of the present couple).
自古以来，世界各地的许多社会都有近亲结婚的现象，尤其是在印度南部。近亲结婚在人口健康方面起着重要作用，导致后代死亡的疾病是有害隐性基因的结果。为了评估近亲结婚中祖先近亲关系对死亡率的影响，我们收集了来自印度安得拉邦奇图尔区三个内婚制社区（阿库托塔·雷迪、奥德和马迪加）的1500名女性的数据。每个社区有500名女性。对于每一对婚姻，我们绘制了一份家族谱系，向上延伸到配偶双方两侧的两代前人，以确定近亲关系的发生率和模式，并获取有关生育和死亡率的详细信息。当考虑到所有三个社区中女性、女性父母以及（女性）丈夫父母的所有婚姻时，我们观察到近亲婚姻和非近亲婚姻之间的死亡率存在显著差异。在近亲繁殖中，较早几代的后代可能（在不利条件下）将有害基因传递给了较晚几代，这导致了（当前夫妇的后代中）繁殖方面的负面影响。
