Asha Bai P V, John T J, Subramaniam V R
Trop Geogr Med. 1981 Sep;33(3):275-80.
The effect of consanguinity on fertility, reproductive loss and developmental disorders were studied in 156 consanguineous marriages in comparison with 221 non-consanguineous marriages. Although fertility was greater (P less than 0.05) in consanguineous than in non-consanguineous marriages, the number of living children were approximately equal in both groups, on account of increased child mortality in the former (P less than 0.05). The frequencies of abortion and stillbirth were (also) approximately equal in both groups. Developmental anomalies were significantly more frequent (P less than 0.001) among the offspring of consanguineous parents. These results indicate the continued presence of deleterious genes in this population, in spite of the practice of consanguinity over many generations.
对156例近亲婚姻与221例非近亲婚姻进行了研究，以探讨近亲关系对生育力、生殖损失和发育障碍的影响。尽管近亲婚姻中的生育力高于非近亲婚姻（P<0.05），但由于前者儿童死亡率增加（P<0.05），两组的存活子女数量大致相等。两组的流产和死产频率也大致相等。近亲父母的后代中发育异常明显更为常见（P<0.001）。这些结果表明，尽管该人群中存在多代近亲通婚现象，但有害基因仍持续存在。
