Pekkala S, Albert M L, Spiro A, Erkinjuntti T
Department of Speech Sciences, University of Helsinki, Helsinki, Finland.
Dement Geriatr Cogn Disord. 2008;25(2):109-14. doi: 10.1159/000112476. Epub 2007 Dec 13.
BACKGROUND/AIMS AND METHODS: Perseveration is common in Alzheimer's disease (AD). We document the type and quantitative burden of perseveration as cognitive decline progresses from normal aging (n = 30) through mild AD (n = 20) to moderate AD (n = 20) by administering a semantic verbal fluency task.
We found perseveration to increase significantly with increasing severity of AD and different types of perseveration that distinguish the subject groups in a statistically significant manner. Recurrent and continuous perseverations appear early in AD. As the disease progresses in severity into moderate stage, the number of recurrent and continuous perseverations increases, and stuck-in-set perseverations emerge.
The different types of perseveration are likely to reflect the progressive deterioration of different brain regions in AD.
背景/目的与方法：持续性重复行为在阿尔茨海默病（AD）中很常见。我们通过进行一项语义言语流畅性任务，记录了随着认知能力从正常衰老（n = 30）经轻度AD（n = 20）发展到中度AD（n = 20）而出现的持续性重复行为的类型和定量负担。
我们发现持续性重复行为随着AD严重程度的增加而显著增加，且不同类型的持续性重复行为以具有统计学意义的方式区分了各受试者组。反复性和持续性的持续性重复行为在AD早期出现。随着疾病严重程度发展到中度阶段，反复性和持续性的持续性重复行为数量增加，且出现了固着于集的持续性重复行为。
不同类型的持续性重复行为可能反映了AD中不同脑区的进行性退化。
