Flory Janine D, Xu Ke, New Antonia S, Finch Thembi, Goldman David, Siever Larry J
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
Psychiatr Genet. 2007 Dec;17(6):344-6. doi: 10.1097/YPG.0b013e3281c8f126.
Aggression is associated with the 'low' activity allele (Met) of the functional Val158Met polymorphism among people with schizophrenia spectrum disorders relative to the 'high' activity (Val) allele. We examined this polymorphism in a sample of 112 people with axis II personality disorders. Participants completed the Buss Durkee Hostility Inventory. Two single nucleotide polymorphisms in the COMT gene were genotyped in these participants classified as 'white' according to US Census Bureau definitions. We failed to observe an association between the Val158Met allele and aggression but observed an association between self-reported aggression and the G allele of a biallelic polymorphism located in the 3'' UTR (rs16559). This allele is less prevalent among schizophrenics and is associated with lower COMT expression in the brain. These findings provide limited support for a role of COMT in modulating aggressive behavior, and are extended to people with personality disorders.
在精神分裂症谱系障碍患者中，相对于“高”活性（Val）等位基因，攻击性与功能性Val158Met多态性的“低”活性等位基因（Met）相关。我们在112名患有轴II人格障碍的样本中检测了这种多态性。参与者完成了布斯-杜克敌意量表。根据美国人口普查局的定义，对这些被归类为“白人”的参与者的COMT基因中的两个单核苷酸多态性进行了基因分型。我们未观察到Val158Met等位基因与攻击性之间的关联，但观察到自我报告的攻击性与位于3''UTR（rs16559）的双等位基因多态性的G等位基因之间存在关联。该等位基因在精神分裂症患者中不太常见，并且与大脑中较低的COMT表达相关。这些发现为COMT在调节攻击行为中的作用提供了有限的支持，并扩展到了人格障碍患者。
