Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Germany.
Acta Psychiatr Scand. 2010 Aug;122(2):110-7. doi: 10.1111/j.1600-0447.2009.01501.x. Epub 2009 Nov 10.
We analyzed i) the effects of serious life events (SLE) on impulsive aggression, and ii) modulating effects of the COMT Val(158)Met polymorphism on the association between SLEs and impulsive aggression in borderline personality disorder (BPD).
One hundred and twelve female BPD patients from Germany were included in this study. Impulsive aggression was assessed by the Buss-Durkee-Hostility Inventory (BDHI).
Childhood sexual abuse was associated with lower BDHI sum score (P = 0.003). In COMT Val(158)Val carriers, but not in Val/Met and Met/Met carriers, childhood sexual abuse and the cumulative number of SLEs were associated with lower BDHI sum scores (P < 0.05).
This study analyzing a specific gene x environment interaction in female BPD patients suggests an association between SLEs and impulsive aggression, as well as a modulating effect of the COMT Val(158)Val genotype on the relation between SLEs and impulsive aggression.
我们分析了 i）严重生活事件（SLE）对冲动性攻击的影响，以及 ii）COMT Val（158）Met 多态性对边缘型人格障碍（BPD）中 SLE 与冲动性攻击之间关联的调节作用。
本研究纳入了 112 名来自德国的女性 BPD 患者。冲动性攻击通过 Buss-Durkee-Hostility Inventory（BDHI）进行评估。
童年性虐待与 BDHI 总分较低相关（P = 0.003）。在 COMT Val（158）Val 纯合子中，但在 Val/Met 和 Met/Met 携带者中并非如此，童年性虐待和 SLE 总数与 BDHI 总分较低相关（P < 0.05）。
这项针对女性 BPD 患者特定基因 x 环境相互作用的研究表明，SLE 与冲动性攻击之间存在关联，以及 COMT Val（158）Val 基因型对 SLE 与冲动性攻击之间关系的调节作用。
