Lessard Andréa, Maltais François, Boulet Louis-Philippe
Université Laval, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Université Laval, 2725 Chemin Sainte-Foy, G1V 4G5 Québec, Canada.
Expert Opin Pharmacother. 2008 Jan;9(1):83-93. doi: 10.1517/14656566.9.1.83.
The prevalence of obesity has noticeably increased worldwide. The clinician is now frequently facing the challenge of managing patients with concomitant chronic obstructive pulmonary disease (COPD) or asthma and obesity. Obesity is often associated with a poorer control of these chronic respiratory diseases and the optimal management of these conditions in the presence of obesity remains to be determined. Herein, the authors review the present understanding of the influence of obesity in the development, clinical manifestations and management of asthma and COPD. The influence of weight loss, response to present therapies as well as new targets for the treatment of COPD and asthma in obese subjects are also discussed, in addition to future directions for research.
肥胖症在全球范围内的患病率显著上升。临床医生如今经常面临管理同时患有慢性阻塞性肺疾病（COPD）或哮喘以及肥胖症患者的挑战。肥胖症往往与这些慢性呼吸道疾病的控制不佳相关，而在存在肥胖症的情况下，这些病症的最佳管理仍有待确定。在此，作者回顾了目前对肥胖症在哮喘和COPD的发展、临床表现及管理方面影响的认识。此外，还讨论了减肥的影响、对现有疗法的反应以及肥胖症患者中COPD和哮喘治疗的新靶点，以及未来的研究方向。
