Arumugam Thiruma V, Selvaraj Pradeep K, Woodruff Trent M, Mattson Mark P
Texas Tech University Health Sciences Center, Department of Pharmaceutical Sciences, School of Pharmacy, Amarillo, Texas 79106, USA.
Expert Opin Ther Targets. 2008 Jan;12(1):19-29. doi: 10.1517/14728222.12.1.19.
Intravenous immunoglobulin (IVIG) is a therapeutic modality approved for the treatment of autoimmune disorders.
This review discusses how IVIG can prevent brain damage following ischemic stroke and discuss the potential mechanisms of action.
Medline and the world wide web were searched and the relevant literature was classified under the following categories: IVIG, IVIG mechanism of action, and ischemic stroke injury mechanisms.
RESULTS/CONCLUSION: Brain ischemia induces an inflammatory response that contributes to neuronal cell death. Because of its ability to block multiple molecular events, IVIG may have particularly strong neuroprotective action against ischemic brain injury. In light of the extensive clinical experience with IVIG for other indications, development of clinical trials to evaluate the use of IVIG in human stroke patients are warranted.
静脉注射免疫球蛋白（IVIG）是一种被批准用于治疗自身免疫性疾病的治疗方式。
本综述讨论IVIG如何预防缺血性中风后的脑损伤，并探讨其潜在作用机制。
检索了医学文献数据库（Medline）和万维网，并将相关文献分类如下：IVIG、IVIG作用机制和缺血性中风损伤机制。
结果/结论：脑缺血会引发炎症反应，导致神经元细胞死亡。由于IVIG能够阻断多种分子事件，它可能对缺血性脑损伤具有特别强的神经保护作用。鉴于IVIG在其他适应症方面有着广泛的临床经验，开展临床试验以评估IVIG在人类中风患者中的应用是有必要的。
