关于神经节苷脂在神经末梢中作用的生化证据。

Biochemical evidence on the role of gangliosides in nerve-endings.

作者信息

Morgan I G, Tettamanti G, Gombos G

出版信息

Adv Exp Med Biol. 1976;71:137-50. doi: 10.1007/978-1-4614-4614-9_9.

Abstract

From the biochemical and developmental data in the literature, there appears to be some specific relationship of gangliosides to synapses. Whether the concentration of polysialo-gangliosides is located in the immediately pre-synaptic part of the neuronal plasma membrane is not known. There are many unanswered questions about the gangliosides, which we have attempted to pose in this article. There are as many hypotheses about roles for gangliosides, and virtually no data to back them up. In fact there are not even real indications of possible functions. We believe that it will be very difficult to define the functions of gangliosides until more of the basic questions are answered-even if their synaptic localization is a constant temptation to speculate.

摘要

从文献中的生化和发育数据来看，神经节苷脂与突触之间似乎存在某种特定关系。多唾液酸神经节苷脂的浓度是否位于神经元质膜紧邻突触前的部分尚不清楚。关于神经节苷脂，有许多问题尚未得到解答，我们试图在本文中提出这些问题。关于神经节苷脂的作用有很多假说，但几乎没有数据支持它们。实际上，甚至没有关于其可能功能的真实迹象。我们认为，在更多基本问题得到解答之前，很难确定神经节苷脂的功能——即使它们在突触处的定位一直吸引着人们进行推测。