Kim Mi-Hyoung, Joo Hong-Gu
Department of Veterinary Medicine, College of Applied Life Sciences, Cheju National University, 66 Jejudaehakno, Ara-1-dong, Jeju-si, Jeju 690-756, Republic of Korea.
Immunol Lett. 2008 Jan 29;115(2):138-43. doi: 10.1016/j.imlet.2007.10.016. Epub 2007 Nov 26.
Fucoidan is a polysaccharide purified from the brown seaweed Fucus vesiculosus. Although some effects of fucoidan on immune functions have been elucidated, there have been no studies concerning the immunomodulatory effects of fucoidan on dendritic cells (DCs), which are powerful antigen-presenting cells. In this study, fucoidan increased the viability of DCs, the production of interleukin-12 and tumor necrosis factor-alpha, and the expression of major histocompatibility complex class I, class II, CD54, and CD86 molecules. Furthermore, fucoidan-treated DCs showed decreased antigen uptake and increased proliferation of allogeneic splenocytes. In a study of the transcriptional regulation effects of fucoidan, translocation of p65 molecules of nuclear factor-kappaB (NF-kappaB) from the cytosol to the nucleus was clearly observed in fucoidan-treated DCs. Taken together, the results suggest that fucoidan has immunostimulating and maturing effects on DCs, via a pathway involving at least NF-kappaB.
岩藻依聚糖是一种从褐藻墨角藻中提纯的多糖。尽管岩藻依聚糖对免疫功能的一些作用已得到阐明，但尚无关于岩藻依聚糖对树突状细胞（DCs）免疫调节作用的研究，而树突状细胞是强大的抗原呈递细胞。在本研究中，岩藻依聚糖提高了树突状细胞的活力、白细胞介素-12和肿瘤坏死因子-α的产生，以及主要组织相容性复合体I类、II类、CD54和CD86分子的表达。此外，经岩藻依聚糖处理的树突状细胞显示出抗原摄取减少以及同种异体脾细胞增殖增加。在一项关于岩藻依聚糖转录调控作用的研究中，在经岩藻依聚糖处理的树突状细胞中清楚地观察到核因子-κB（NF-κB）的p65分子从胞质溶胶向细胞核的转位。综上所述，结果表明岩藻依聚糖通过至少涉及NF-κB的途径对树突状细胞具有免疫刺激和成熟作用。
