Marine College, Shandong University, Weihai 264209, China.
School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Mar Drugs. 2022 May 25;20(6):349. doi: 10.3390/md20060349.
Colorectal cancer, a malignant tumor with high mortality, has a poor prognosis due to drug resistance and toxicity in clinical surgery and chemotherapy. Thus, finding safer and more efficient drugs for clinical trials is vital and urgent. Natural marine compounds, with rich resources and original chemical structures, are applied widely in anticancer treatments. We provide a systematic overview of recently reported marine compounds such as alkaloids, peptides, terpenoids, polysaccharides, and carotenoids from in vitro, in vivo, and clinical studies. The in vitro studies summarized the marine origins and pharmacological mechanisms, including anti-proliferation, anti-angiogenesis, anti-migration, anti-invasion, the acceleration of cycle arrest, and the promotion of tumor apoptosis, of various compounds. The in vivo studies outlined the antitumor effects of marine compounds on colorectal cancer model mice and evaluated their efficacy in terms of tumor inhibition, hepatotoxicity, and nephrotoxicity. The clinical studies summarized the major chemical classifications and targets of action of the clinical drugs that have entered clinical approval and completed approval for marine anticancer. In summary, we present the current situation regarding the application of natural anti-colorectal cancer marine compounds and prospects for their clinical application.
结直肠癌是一种死亡率较高的恶性肿瘤，由于临床手术和化疗中的耐药性和毒性，预后较差。因此，寻找更安全、更有效的药物进行临床试验至关重要且紧迫。天然海洋化合物具有丰富的资源和原始的化学结构，在抗癌治疗中得到广泛应用。我们系统地综述了最近报道的海洋化合物，如生物碱、肽、萜类、多糖和类胡萝卜素，包括来自体外、体内和临床研究的这些化合物。体外研究总结了各种化合物的海洋来源和药理机制，包括抗增殖、抗血管生成、抗迁移、抗侵袭、加速细胞周期停滞和促进肿瘤细胞凋亡。体内研究概述了海洋化合物对结直肠癌模型小鼠的抗肿瘤作用，并根据肿瘤抑制、肝毒性和肾毒性评估了它们的疗效。临床研究总结了已进入临床批准并已完成批准用于海洋抗癌的临床药物的主要化学分类和作用靶点。总之，我们介绍了天然抗结直肠癌海洋化合物的应用现状及其临床应用前景。
