Wengström Y
Division of Nursing, Department of Neurobiology, Care Science and Society, Karolinska Institutet, 23300, 141 83 Huddinge, Sweden.
Breast. 2008 Jun;17(3):227-38. doi: 10.1016/j.breast.2007.11.001. Epub 2008 Feb 20.
Inhibiting estrogen production is a common means of preventing breast cancer recurrence. The aromatase inhibitors (AIs) are becoming the preferred treatment over tamoxifen as adjuvant therapy for postmenopausal women with hormone-sensitive early breast cancer. Like all adjuvant therapies, AIs have adverse events (AEs) associated with their use, many of which resemble symptoms common to menopause. Because of the greater efficacy of AIs in preventing breast cancer recurrence over tamoxifen, these AEs may be considered tolerable by many patients and often can be effectively managed and/or prevented. Educating patients about anticipated AEs may help them understand, accept, and cope with these AEs. This article reviews the AEs associated with different adjuvant AI treatments and highlights some strategies to manage them effectively. It also highlights the importance of patient education regarding AI therapy and involvement in treatment decisions, which may lead to better long-term adherence and ultimately to better outcomes.
抑制雌激素生成是预防乳腺癌复发的常用方法。芳香化酶抑制剂(AIs)正逐渐成为他莫昔芬的首选替代药物,用于激素敏感型早期乳腺癌绝经后女性的辅助治疗。与所有辅助治疗一样,AIs在使用过程中会产生不良事件(AEs),其中许多类似于绝经常见症状。由于AIs在预防乳腺癌复发方面比他莫昔芬更有效,许多患者可能认为这些不良事件是可以耐受的,并且通常可以得到有效管理和/或预防。对患者进行有关预期不良事件的教育可能有助于他们理解、接受并应对这些不良事件。本文综述了与不同辅助性AI治疗相关的不良事件,并重点介绍了一些有效管理这些不良事件的策略。文章还强调了对患者进行AI治疗教育以及让患者参与治疗决策的重要性,这可能会带来更好的长期依从性,并最终带来更好的治疗效果。