Lambert Leah K, Balneaves Lynda G, Howard A Fuchsia
School of Nursing, University of British Columbia, T201-2211 Wesbrook Mall, Vancouver, BC V6T 2B5; British Columbia Cancer, 600 W 10th Ave, Vancouver, BC V5Z 4E6.
College of Nursing, Rady Faculty of Health Sciences, University of Manitoba, 89 Curry Place, Helen Glass Centre for Nursing, Winnipeg, MB R3T 2N2.
Can Oncol Nurs J. 2021 May 1;31(2):221-227. eCollection 2021 Spring.
Adjuvant endocrine therapy (AET) is a highly efficacious treatment that significantly reduces breast cancer recurrence and mortality for women with hormone-receptor positive breast cancer. Yet, many women do not adhere to prescribed AET. The overarching aim of this research was to gain a better understanding of why a significant number of women diagnosed with breast cancer have suboptimal adherence to AET. A mixed-methods approach was used to explore the personal, social, and structural factors influencing breast cancer survivors' AET adherence, including: (1) an integrative review of patient-reported factors associated with AET adherence; and (2) interviews with breast cancer survivors prescribed AET. In this paper, we summarize and discuss the key contributions of both phases of this research, implication for clinical practice, and how we might leverage the expertise of nurses in practicing to full scope to address the complex needs of breast cancer survivors prescribed AET.
辅助内分泌治疗（AET）是一种高效的治疗方法，可显著降低激素受体阳性乳腺癌女性的乳腺癌复发率和死亡率。然而，许多女性并未坚持规定的AET治疗。本研究的总体目标是更好地理解为什么大量被诊断为乳腺癌的女性对AET的依从性欠佳。采用了混合研究方法来探究影响乳腺癌幸存者AET依从性的个人、社会和结构因素，包括：（1）对与AET依从性相关的患者报告因素进行综合综述；以及（2）对接受AET治疗的乳腺癌幸存者进行访谈。在本文中，我们总结并讨论了本研究两个阶段的关键贡献、对临床实践的启示，以及我们如何利用护士的专业知识，充分发挥其作用，以满足接受AET治疗的乳腺癌幸存者的复杂需求。
