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本文引用的文献

1
Raster3D: photorealistic molecular graphics.Raster3D：逼真的分子图形。
Methods Enzymol. 1997;277:505-24. doi: 10.1016/s0076-6879(97)77028-9.
2
Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies.利用单克隆抗体对高致病性H5N1流感病毒血凝素分子进行表位作图。
J Virol. 2007 Dec;81(23):12911-7. doi: 10.1128/JVI.01522-07. Epub 2007 Sep 19.
3
Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial.一种佐剂化重组H5N1大流行性流感原型疫苗的抗原节省和交叉反应性免疫：一项随机对照试验。
Lancet. 2007 Aug 18;370(9587):580-9. doi: 10.1016/S0140-6736(07)61297-5.
4
Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity.通过具有改变的受体结合特异性的禽H5流感血凝素突变体进行免疫接种。
Science. 2007 Aug 10;317(5839):825-8. doi: 10.1126/science.1135165.
5
Genome analysis linking recent European and African influenza (H5N1) viruses.将近期欧洲和非洲甲型流感（H5N1）病毒联系起来的基因组分析。
Emerg Infect Dis. 2007 May;13(5):713-8. doi: 10.3201/eid1305.070013.
6
New strain of influenza A virus (H5N1), Thailand.甲型流感病毒（H5N1）新毒株，泰国
Emerg Infect Dis. 2007 Mar;13(3):506-7. doi: 10.3201/eid1303.061103.
7
Antigenic and genetic characteristics of H5N1 viruses and candidate H5N1 vaccine viruses developed for potential use as pre-pandemic vaccines, March 2007.2007年3月H5N1病毒的抗原性和基因特征以及为用作大流行前疫苗而研发的候选H5N1疫苗病毒
Wkly Epidemiol Rec. 2007 May 11;82(19):164-7.
8
Inefficient transmission of H5N1 influenza viruses in a ferret contact model.H5N1流感病毒在雪貂接触模型中的低效传播。
J Virol. 2007 Jul;81(13):6890-8. doi: 10.1128/JVI.00170-07. Epub 2007 Apr 25.
9
H5N1 influenza viruses in Lao People's Democratic Republic.老挝人民民主共和国的H5N1流感病毒
Emerg Infect Dis. 2006 Oct;12(10):1593-5. doi: 10.3201/eid1210.060658.
10
Vaccines developed for H5 highly pathogenic avian influenza in China.中国研发的针对H5高致病性禽流感的疫苗。
Ann N Y Acad Sci. 2006 Oct;1081:182-92. doi: 10.1196/annals.1373.022.

2002年至2007年亚洲禽流感H5N1病毒的抗原特征

Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007.

作者信息

Wu Wai Lan, Chen Yixin, Wang Pui, Song Wenjun, Lau Siu-Ying, Rayner Jane M, Smith Gavin J D, Webster Robert G, Peiris J S Malik, Lin Tianwei, Xia Ningshao, Guan Yi, Chen Honglin

机构信息

State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, People's Republic of China.

出版信息

J Virol. 2008 Feb;82(4):1798-807. doi: 10.1128/JVI.02256-07. Epub 2007 Dec 12.

DOI:10.1128/JVI.02256-07
PMID:18077726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2258718/
Abstract

Antigenic profiles of post-2002 H5N1 viruses representing major genetic clades and various geographic sources were investigated using a panel of 17 monoclonal antibodies raised from five H5N1 strains. Four antigenic groups from seven clades of H5N1 virus were distinguished and characterized based on their cross-reactivity to the monoclonal antibodies in hemagglutination inhibition and cell-based neutralization assays. Genetic polymorphisms associated with the variation of antigenicity of H5N1 strains were identified and further verified in antigenic analysis with recombinant H5N1 viruses carrying specific mutations in the hemagglutinin protein. Modification of some of these genetic variations produced marked improvement to the immunogenicity and cross-reactivity of H5N1 strains in assays utilizing monoclonal antibodies and ferret antisera raised against clade 1 and 2 H5N1 viruses, suggesting that these sites represent antigenically significant amino acids. These results provide a comprehensive antigenic profile for H5N1 virus strains circulating in recent years and will facilitate the recognition of emerging antigenic variants of H5N1 virus and aid in the selection of vaccine strains.

摘要

利用从5株H5N1病毒株产生的一组17种单克隆抗体，对代表主要基因分支和不同地理来源的2002年后H5N1病毒的抗原特性进行了研究。基于H5N1病毒7个分支在血凝抑制试验和基于细胞的中和试验中与单克隆抗体的交叉反应性，区分并鉴定了4个抗原组。鉴定出与H5N1毒株抗原性变异相关的基因多态性，并在对血凝素蛋白携带特定突变的重组H5N1病毒进行的抗原分析中进一步验证。在利用针对1和2分支H5N1病毒产生的单克隆抗体和雪貂抗血清进行的试验中，对其中一些基因变异的修饰显著提高了H5N1毒株的免疫原性和交叉反应性，表明这些位点代表具有抗原意义的氨基酸。这些结果为近年来流行的H5N1病毒株提供了全面的抗原特性，将有助于识别H5N1病毒新出现的抗原变异体，并有助于疫苗株的选择。