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Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity.
Science. 2007 Aug 10;317(5839):825-8. doi: 10.1126/science.1135165.
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A novel humanized antibody neutralizes H5N1 influenza virus via two different mechanisms.
J Virol. 2015 Apr;89(7):3712-22. doi: 10.1128/JVI.03014-14. Epub 2015 Jan 21.
3
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus.
Science. 2006 Apr 21;312(5772):404-10. doi: 10.1126/science.1124513. Epub 2006 Mar 16.
4
Enhanced Human-Type Receptor Binding by Ferret-Transmissible H5N1 with a K193T Mutation.
J Virol. 2018 Apr 27;92(10). doi: 10.1128/JVI.02016-17. Print 2018 May 15.
6
H5N1 influenza A virus with K193E and G225E double mutations in haemagglutinin is attenuated and immunogenic in mice.
J Gen Virol. 2015 Sep;96(9):2522-2530. doi: 10.1099/vir.0.000193. Epub 2015 May 21.
7
Glycans on influenza hemagglutinin affect receptor binding and immune response.
Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18137-42. doi: 10.1073/pnas.0909696106. Epub 2009 Oct 12.

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H5N1 2.3.4.4b: a review of mammalian adaptations and risk of pandemic emergence.
J Gen Virol. 2025 Jun;106(6). doi: 10.1099/jgv.0.002109.
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Phylodynamics and Molecular Mutations of the Hemagglutinin Affecting Global Transmission and Host Adaptation of H5Nx Viruses.
Transbound Emerg Dis. 2023 Apr 14;2023:8855164. doi: 10.1155/2023/8855164. eCollection 2023.
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Mutations in the influenza virus, primarily H5N1, enhance the virus's virulence, favor receptor interaction, and increase drug resistance.
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Characterization of novel highly pathogenic avian influenza A(H5N6) clade 2.3.4.4b virus in wild birds, East China, 2024.
Virol Sin. 2025 Apr;40(2):284-287. doi: 10.1016/j.virs.2025.01.002. Epub 2025 Jan 21.

本文引用的文献

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A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission.
Science. 2007 Feb 2;315(5812):655-9. doi: 10.1126/science.1136212.
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Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination.
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15987-91. doi: 10.1073/pnas.0607564103. Epub 2006 Oct 16.
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Glycan microarray technologies: tools to survey host specificity of influenza viruses.
Nat Rev Microbiol. 2006 Nov;4(11):857-64. doi: 10.1038/nrmicro1530. Epub 2006 Oct 2.
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Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus.
Science. 2006 Apr 21;312(5772):404-10. doi: 10.1126/science.1124513. Epub 2006 Mar 16.
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Development of effective vaccines against pandemic influenza.
Immunity. 2006 Jan;24(1):5-9. doi: 10.1016/j.immuni.2005.12.005.
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The origins of new pandemic viruses: the acquisition of new host ranges by canine parvovirus and influenza A viruses.
Annu Rev Microbiol. 2005;59:553-86. doi: 10.1146/annurev.micro.59.030804.121059.
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Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus.
Science. 2004 Mar 19;303(5665):1866-70. doi: 10.1126/science.1093373. Epub 2004 Feb 5.

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