Donald P R, Doherty E, Van Zyl F J
Department of Paediatrics, Tybgerberg Hospital, Republic of South Africa.
Cent Afr J Med. 1991 Aug;37(8):268-71.
The risk of deafness developing in the unborn child following the use of streptomycin (SM) during pregnancy remains uncertain. We have followed up 30 children whose mothers received SM during pregnancy. One child (3pc), whose mother received SM during the first trimester of pregnancy, had profound unilateral hearing loss which could possibly be ascribed to SM. This child had however, in addition, features of congenital hypotonia and a unilateral single crease. Two further children had conductive deafness which could not be due to SM, associated with serious otitis media. Although the risk to the foetus of hearing loss following the use of SM during pregnancy appears relatively low it should, where possible, be avoided during the first trimester of pregnancy.
孕期使用链霉素（SM）后未出生儿童发生耳聋的风险仍不确定。我们对30名母亲在孕期接受过SM治疗的儿童进行了随访。有一名儿童（占3%），其母亲在孕早期接受过SM治疗，患有严重的单侧听力损失，这可能归因于SM。然而，这名儿童还伴有先天性肌张力低下和单侧单一掌纹的特征。另有两名儿童患有传导性耳聋，这并非由SM所致，而是与严重的中耳炎有关。尽管孕期使用SM后胎儿发生听力损失的风险似乎相对较低，但在孕早期应尽可能避免使用。
