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[盐水矿物水氯镁石(MgCL2·6H2O)标准溶液对大鼠胎儿产前发育的影响]

[Effect of standardized solution of brine mineral bischofit (MgCL2.6H2O) on the antenatal development of rat fetus].

作者信息

Bugaeva L I, Lebedeva S A, Spasov A A

出版信息

Eksp Klin Farmakol. 2007 Jul-Aug;70(4):35-8.

Abstract

A standard solution of mineral bischofit has low toxicity and produces a dose-dependent effect on the antenatal development of rat fetuses. Bischofit in a dose of 0.01 ml/kg and 0.1 ml/kg (daily requirement for magnesium ions) increased the index of fertility and the quality of embryonal development in rats. The index of fertility was reduced and fetal skeleton formation was inhibited after the administration of bischofit in a dose of 1.0 ml/kg.

摘要

标准的矿卤溶液毒性较低,对大鼠胎儿的产前发育产生剂量依赖性影响。剂量为0.01 ml/kg和0.1 ml/kg(镁离子每日需求量)的矿卤增加了大鼠的生育指数和胚胎发育质量。给予1.0 ml/kg剂量的矿卤后,生育指数降低,胎儿骨骼形成受到抑制。

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