Usami M, Sakemi K, Tsuda M, Ohno Y
Eisei Shikenjo Hokoku. 1996(114):16-20.
Teratogenicity of magnesium chloride hexahydrate (MgCl2.6H2O) was examined in rats. Magnesium chloride hexahydrate dissolved in distilled water was given to pregnant Wistar rats by gavage once a day from day 6 through 15 of pregnancy at doses of 0, 200, 400 and 800 mg/kg/day. The pregnant rats were sacrificed on day 20 of pregnancy and their fetuses were examined for malformation. Magnesium chloride hexahydrate caused no increased incidences of fetal malformation, and no toxic signs in the pregnant rats and the fetuses. It was concluded that magnesium chloride hexahydrate has no teratogenicity in rats when given by gavage. The no observed adverse effect level was estimated to be over 800 mg/kg/day for both pregnant rats and rat fetuses.
研究了六水合氯化镁（MgCl₂·6H₂O）对大鼠的致畸性。在妊娠第6天至第15天，将溶于蒸馏水的六水合氯化镁以0、200、400和800mg/kg/天的剂量通过灌胃给予妊娠的Wistar大鼠，每天一次。在妊娠第20天处死妊娠大鼠，并检查其胎儿是否畸形。六水合氯化镁未导致胎儿畸形发生率增加，且对妊娠大鼠和胎儿均无毒性迹象。得出的结论是，通过灌胃给予六水合氯化镁时，其对大鼠无致畸性。对于妊娠大鼠和大鼠胎儿，未观察到不良影响的水平估计超过800mg/kg/天。
