Guglielmi Giuseppe, Stoppino Luca Pio, Placentino Maria Grazia, D'Errico Francesco, Palmieri Francesco
Department of Radiology, University of Foggia, Viale Luigi Pinto, Foggia 71100, Italy.
Eur J Radiol. 2009 Jan;69(1):173-8. doi: 10.1016/j.ejrad.2007.09.040. Epub 2007 Dec 19.
To evaluate the reproducibility of a semi-automated system for vertebral morphometry (MorphoXpress) in a large multi-centre trial.
The study involved 132 clinicians (no radiologist) with different levels of experience across 20 osteo-centres in Italy. All have received training in using MorphoXpress. An expert radiologist was also involved providing data used as standard of reference. The test image originate from normal clinical activity and represent a variety of normal, under and over exposed films, indicating both normal anatomy and vertebral deformities. The image was represented twice to the clinicians in a random order. Using the software, the clinicians initially marked the midpoints of the upper and lower vertebrae to include as many of the vertebrae (T5-L4) as practical within each given image. MorphoXpress performs the localisation of all morphometric points based on statistical model-based vision system. Intra-operator as well inter-operator measurement of agreement was calculated using the coefficient of variation and the mean and standard deviation of the difference of two measurements to check their agreement.
The overall intra-operator mean differences in vertebral heights is 1.61+/-4.27% (1 S.D.). The overall intra-operator coefficient of variation is 3.95%. The overall inter-operator mean differences in vertebral heights is 2.93+/-5.38% (1 S.D.). The overall inter-operator coefficient of variation is 6.89%.
The technology tested here can facilitate reproducible quantitative morphometry suitable for large studies of vertebral deformities.
在一项大型多中心试验中评估一种用于椎体形态测量的半自动系统（MorphoXpress）的可重复性。
该研究纳入了意大利20个骨中心的132名不同经验水平的临床医生（无放射科医生）。所有人都接受了使用MorphoXpress的培训。还邀请了一位专家放射科医生提供用作参考标准的数据。测试图像来自正常临床活动，代表各种正常、曝光不足和曝光过度的影像，显示了正常解剖结构和椎体畸形。图像以随机顺序向临床医生展示两次。临床医生使用该软件首先标记上下椎体的中点，以便在每个给定图像中尽可能多地纳入椎体（T5 - L4）。MorphoXpress基于基于统计模型的视觉系统进行所有形态测量点的定位。使用变异系数以及两次测量差值的均值和标准差来计算操作者内和操作者间测量的一致性，以检查他们的一致性。
椎体高度的总体操作者内平均差异为1.61±4.27%（标准差）。总体操作者内变异系数为3.95%。椎体高度的总体操作者间平均差异为2.93±5.38%（标准差）。总体操作者间变异系数为6.89%。
此处测试的技术可促进适用于椎体畸形大型研究的可重复定量形态测量。
