Gouin Jean-Philippe, Kiecolt-Glaser Janice K, Malarkey William B, Glaser Ronald
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA.
Brain Behav Immun. 2008 Jul;22(5):699-708. doi: 10.1016/j.bbi.2007.10.013. Epub 2007 Dec 19.
Certain patterns of anger expression have been associated with maladaptive alterations in cortisol secretion, immune functioning, and surgical recovery. We hypothesized that outward and inward anger expression and lack of anger control would be associated with delayed wound healing. A sample of 98 community-dwelling participants received standardized blister wounds on their non-dominant forearm. After blistering, the wounds were monitored daily for 8 days to assess speed of repair. Logistic regression was used to distinguish fast and slow healers based on their anger expression pattern. Individuals exhibiting lower levels of anger control were more likely to be categorized as slow healers. The anger control variable predicted wound repair over and above differences in hostility, negative affectivity, social support, and health behaviors. Furthermore, participants with lower levels of anger control exhibited higher cortisol reactivity during the blistering procedure. This enhanced cortisol secretion was in turn related to longer time to heal. These findings suggest that the ability to regulate the expression of one's anger has a clinically relevant impact on wound healing.
某些愤怒表达模式与皮质醇分泌、免疫功能和手术恢复的适应不良改变有关。我们假设，外向和内向的愤怒表达以及缺乏愤怒控制与伤口愈合延迟有关。98名社区居民参与者的样本在其非优势前臂上接受了标准化的水泡伤口。水泡形成后，每天对伤口进行8天的监测，以评估修复速度。使用逻辑回归根据他们的愤怒表达模式区分愈合快和慢的人。表现出较低愤怒控制水平的个体更有可能被归类为愈合缓慢者。愤怒控制变量在敌意、消极情感、社会支持和健康行为差异之外预测了伤口修复。此外，愤怒控制水平较低的参与者在水泡形成过程中表现出较高的皮质醇反应性。这种增强的皮质醇分泌反过来又与更长的愈合时间有关。这些发现表明，调节愤怒表达的能力对伤口愈合具有临床相关影响。
