周细胞与眼部疾病

Pericytes and ocular diseases.

作者信息

Motiejūnaite Rūta, Kazlauskas Andrius

机构信息

Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA.

出版信息

Exp Eye Res. 2008 Feb;86(2):171-7. doi: 10.1016/j.exer.2007.10.013. Epub 2007 Nov 5.

DOI:10.1016/j.exer.2007.10.013

PMID:18078933

Abstract

Pericytes are vascular mural cells which play multiple roles in angiogenesis and maintenance of blood vessel morphology and stability. In this review, we analyze recent data on the participation of pericytes in the pathogenesis of proliferative and non-proliferative diabetic retinopathy, as well as an emerging role in other angiogenic ocular diseases such as retinopathy of prematurity. Ways to exploit pericytes as targets for treatment of ocular diseases are discussed.

摘要

周细胞是血管壁细胞，在血管生成以及血管形态和稳定性的维持中发挥多种作用。在本综述中，我们分析了周细胞参与增殖性和非增殖性糖尿病视网膜病变发病机制的最新数据，以及其在早产儿视网膜病变等其他血管生成性眼病中的新作用。还讨论了将周细胞作为眼病治疗靶点的方法。