腹侧被盖区及其他区域GABA能突触的长时程增强。
LTP of GABAergic synapses in the ventral tegmental area and beyond.
作者信息
Nugent Fereshteh S, Kauer Julie A
机构信息
Brown University, Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, RI 02912, USA.
出版信息
J Physiol. 2008 Mar 15;586(6):1487-93. doi: 10.1113/jphysiol.2007.148098. Epub 2007 Dec 13.
Abstract
One of the mechanisms by which the experience-dependent reorganization of neural circuitry can occur is through changes in synaptic strength. Almost every excitatory synapse in the mammalian brain exhibits LTP (long-term potentiation) or LTD (long-term depression), two cellular mechanisms of synaptic plasticity. However, LTP and LTD have been reported much more rarely at fast inhibitory GABA(A) receptor synapses. Our recent study suggests that in vivo morphine initiates a long-lasting alteration of GABAergic synapses in the ventral tegmental area (VTA) by blocking the mechanisms required for LTP of GABAergic synapses. Here we put this work into the context of other examples of synaptic plasticity at GABAergic synapses.
摘要
神经回路依赖经验的重组能够发生的一种机制是通过突触强度的改变。哺乳动物大脑中几乎每一个兴奋性突触都表现出长时程增强（LTP）或长时程抑制（LTD），这是突触可塑性的两种细胞机制。然而，在快速抑制性GABA(A)受体突触处，LTP和LTD的报道要少得多。我们最近的研究表明，体内吗啡通过阻断GABA能突触LTP所需的机制，引发腹侧被盖区（VTA）GABA能突触的长期改变。在此，我们将这项工作置于GABA能突触处其他突触可塑性例子的背景中。
相似文献
1
LTP of GABAergic synapses in the ventral tegmental area and beyond.腹侧被盖区及其他区域GABA能突触的长时程增强。
J Physiol. 2008 Mar 15;586(6):1487-93. doi: 10.1113/jphysiol.2007.148098. Epub 2007 Dec 13.
2
Synaptic function and plasticity in identified inhibitory inputs onto VTA dopamine neurons.腹侧被盖区多巴胺神经元识别性抑制性传入的突触功能和可塑性。
Eur J Neurosci. 2018 May;47(10):1208-1218. doi: 10.1111/ejn.13879. Epub 2018 Mar 13.
3
Synaptic Plasticity at Inhibitory Synapses in the Ventral Tegmental Area Depends upon Stimulation Site.腹侧被盖区抑制性突触的突触可塑性取决于刺激部位。
eNeuro. 2019 Nov 15;6(6). doi: 10.1523/ENEURO.0137-19.2019. Print 2019 Nov/Dec.
4
PKG and PKA signaling in LTP at GABAergic synapses.γ-氨基丁酸能突触处长时程增强中的PKG和PKA信号传导
Neuropsychopharmacology. 2009 Jun;34(7):1829-42. doi: 10.1038/npp.2009.5. Epub 2009 Feb 4.
5
Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area.滥用药物和压力会损害腹侧被盖区抑制性突触的 LTP。
Eur J Neurosci. 2010 Jul;32(1):108-17. doi: 10.1111/j.1460-9568.2010.07256.x.
6
Spike timing-dependent plasticity at GABAergic synapses in the ventral tegmental area.腹侧被盖区 GABA 能突触的尖峰时间依赖性可塑性。
J Physiol. 2013 Oct 1;591(19):4699-710. doi: 10.1113/jphysiol.2013.257873. Epub 2013 Jul 29.
7
Cell type-specific long-term plasticity at glutamatergic synapses onto hippocampal interneurons expressing either parvalbumin or CB1 cannabinoid receptor.表达囊泡相关蛋白或大麻素 CB1 受体的海马中间神经元上谷氨酸能突触的细胞类型特异性长时程可塑性。
J Neurosci. 2010 Jan 27;30(4):1337-47. doi: 10.1523/JNEUROSCI.3481-09.2010.
8
The endocannabinoid 2-arachidonoylglycerol inhibits long-term potentiation of glutamatergic synapses onto ventral tegmental area dopamine neurons in mice.内源性大麻素 2-花生四烯酰甘油抑制小鼠腹侧被盖区多巴胺神经元谷氨酸能突触的长时程增强。
Eur J Neurosci. 2011 May;33(10):1751-60. doi: 10.1111/j.1460-9568.2011.07648.x. Epub 2011 Mar 17.
9
Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area.腹侧被盖区中多巴胺能和γ-氨基丁酸能细胞上兴奋性突触的特性与可塑性。
J Neurosci. 1999 May 15;19(10):3723-30. doi: 10.1523/JNEUROSCI.19-10-03723.1999.
10
Opioids block long-term potentiation of inhibitory synapses.阿片类药物会阻断抑制性突触的长期增强。
Nature. 2007 Apr 26;446(7139):1086-90. doi: 10.1038/nature05726.
引用本文的文献
1
Dual and plasticity-dependent regulation of cerebello-zona incerta circuits on anxiety-like behaviors.小脑-未定带神经回路对焦虑样行为的双重及可塑性依赖调节
Nat Commun. 2025 Apr 8;16(1):3339. doi: 10.1038/s41467-025-58727-0.
2
Alcohol potentiates multiple GABAergic inputs to dorsal striatum fast-spiking interneurons.酒精增强了背侧纹状体中快速棘波中间神经元的多种 GABA 能传入。
Neuropharmacology. 2023 Jul 1;232:109527. doi: 10.1016/j.neuropharm.2023.109527. Epub 2023 Apr 1.
3
Role of α6-Nicotinic Receptors in Alcohol-Induced GABAergic Synaptic Transmission and Plasticity to Cholinergic Interneurons in the Nucleus Accumbens.α6 型烟碱型乙酰胆碱受体在酒精诱导的伏隔核 GABA 能突触传递和可塑性中的作用。
Mol Neurobiol. 2023 Jun;60(6):3113-3129. doi: 10.1007/s12035-023-03263-5. Epub 2023 Feb 18.
4
Stressed and wired: The effects of stress on the VTA circuits underlying motivated behavior.压力与兴奋：压力对动机行为背后的腹侧被盖区神经回路的影响。
Curr Opin Endocr Metab Res. 2022 Oct;26. doi: 10.1016/j.coemr.2022.100388. Epub 2022 Aug 7.
5
Effects of isoflurane anesthesia on addictive behaviors in rats.异氟烷麻醉对大鼠成瘾行为的影响。
Psychopharmacology (Berl). 2022 Nov;239(11):3621-3632. doi: 10.1007/s00213-022-06236-z. Epub 2022 Sep 15.
6
Functional Interaction Between GABAergic Neurons in the Ventral Tegmental Area and Serotonergic Neurons in the Dorsal Raphe Nucleus.腹侧被盖区γ-氨基丁酸能神经元与中缝背核5-羟色胺能神经元之间的功能相互作用。
Front Neurosci. 2022 May 19;16:877054. doi: 10.3389/fnins.2022.877054. eCollection 2022.
7
Metastable dynamics of neural circuits and networks.神经回路与网络的亚稳态动力学
Appl Phys Rev. 2022 Mar;9(1):011313. doi: 10.1063/5.0062603.
8
Brain is modulated by neuronal plasticity during postnatal development.大脑在出生后发育过程中通过神经元可塑性进行调节。
J Physiol Sci. 2021 Nov 17;71(1):34. doi: 10.1186/s12576-021-00819-9.
9
Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization.α1 肾上腺素能受体在可卡因敏化过程中调节腹侧被盖区多巴胺神经元上的谷氨酸和 GABA 神经传递。
Int J Mol Sci. 2020 Jan 25;21(3):790. doi: 10.3390/ijms21030790.
10
VTA GABA Neurons at the Interface of Stress and Reward.腹侧被盖区 GABA 神经元在应激和奖励的交界处。
Front Neural Circuits. 2019 Dec 5;13:78. doi: 10.3389/fncir.2019.00078. eCollection 2019.
本文引用的文献
1
Synaptic plasticity and addiction.突触可塑性与成瘾
Nat Rev Neurosci. 2007 Nov;8(11):844-58. doi: 10.1038/nrn2234.
2
Refining the roles of GABAergic signaling during neural circuit formation.优化γ-氨基丁酸能信号在神经回路形成过程中的作用。
Trends Neurosci. 2007 Aug;30(8):382-9. doi: 10.1016/j.tins.2007.06.002. Epub 2007 Jun 27.
3
Sustained structural change of GABA(A) receptor-associated protein underlies long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron.γ-氨基丁酸A（GABA(A)）受体相关蛋白的持续结构变化是小脑浦肯野神经元抑制性突触长期增强的基础。
J Neurosci. 2007 Jun 20;27(25):6788-99. doi: 10.1523/JNEUROSCI.1981-07.2007.
4
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.内源性大麻素介导的长期可塑性需要cAMP/PKA信号传导和RIM1α。
Neuron. 2007 Jun 7;54(5):801-12. doi: 10.1016/j.neuron.2007.05.020.
5
Opioids block long-term potentiation of inhibitory synapses.阿片类药物会阻断抑制性突触的长期增强。
Nature. 2007 Apr 26;446(7139):1086-90. doi: 10.1038/nature05726.
6
Potentiation of cortical inhibition by visual deprivation.视觉剥夺对皮质抑制的增强作用。
Nature. 2006 Sep 7;443(7107):81-4. doi: 10.1038/nature05079. Epub 2006 Aug 23.
7
Neural mechanisms of addiction: the role of reward-related learning and memory.成瘾的神经机制：奖赏相关学习与记忆的作用
Annu Rev Neurosci. 2006;29:565-98. doi: 10.1146/annurev.neuro.29.051605.113009.
8
Endocannabinoid-mediated synaptic plasticity in the CNS.内源性大麻素介导的中枢神经系统突触可塑性。
Annu Rev Neurosci. 2006;29:37-76. doi: 10.1146/annurev.neuro.29.051605.112834.
9
Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors.由突触前NMDA受体介导的视觉刺激诱导的GABA能突触长时程抑制。
Nat Neurosci. 2006 Mar;9(3):372-80. doi: 10.1038/nn1649. Epub 2006 Feb 12.
10
Drivers and modulators from push-pull and balanced synaptic input.来自推挽式和平衡突触输入的驱动因素和调节因素。
Prog Brain Res. 2005;149:147-55. doi: 10.1016/S0079-6123(05)49011-1.
Zotero 插件